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Evidence for the transport of a growth factor in a synaptic contact between two nerve cells.

Electron-microscopic image of a section through a chick embryo’s brain.

von Bartheld et al., 1996, Nature 379:830-833.


The five research projects of this COBRE examine different viewpoints of signaling across membranes, utilizing uniquely advantageous model systems. To bridge the widening gap between clinicians and basic scientists, we provide an environment that encourages basic scientists to place their research in a biomedical context. The COBRE strives to gain new biomedical insights that will improve understanding of physiological and pathophysiological processes, ultimately paving the way to treat human diseases.


1. Neurotrophic Signaling in Drosophila, Thomas Kidd, Ph.D.

2. Secretion of Signaling Molecules, Patricia Berninsone, Ph.D.

3. The Roles of Glia and Neural Activity in the Development of Neuromuscular Synapses

    Thomas Gould, Ph.D.

4. Modulation of Mitochondrial Quality Control and Function by Serine/Threonine Kinases

    and Phosphatases in Neurons, Ruben Dagda, Ph.D.

5. Disease-related mitochondrial dynamics and synaptic vesicle recycling at an identified

    synapse, Robert Renden, Ph.D.



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