Steve St. Jeor, Ph.D.

Professor
Department of Microbiology and Immunology 320
School of Medicine
University of Nevada
Reno, NV 89557-0320

Office Phone: (775) 784-4123
Lab Phone: (775) 784-1383
Howard Medical Sceinces, Room 208
Fax: (775) 327-2332
E-mail: stjeor@medicine.nevada.edu

Research Interests:

My laboratory is interested in the pathogenesis of virus diseases. In the overall area of virus pathogenesis we are interested in the regulation of human cytomegalovirus latency and the pathogenesis of New World Hantaviruses. Cytomegalovirus is a member of the herpes group of viruses. It infects a high percentage of the human population but is most common present as a latent virus infection. My laboratory is interested in the mechanism by which the virus maintains its latent infection and how its activation is regulated.

The second area of interest is the pathogenesis of RNA viruses which are present as epizootic diseases diseases. As a model we are investigating the pathogenesis of New World Hantaviruses. There are several approaches we use to understand the pathogenesis of these viruses in their natural rodent hosts. We are studying natural infections by hantaviruses using catch and release studies to investigate natural hantavirus infections. We are also comparing factors associated with virus disease such as the ability of the virus to induce specific inflammatory cytokines that contribute to viral pathogenesis.

Our laboratory uses a variety of approaches to study virus pathogenesis including the following: 1) nucleic acid sequencing; 2)RNAse protection assays and real time PCR to quantitate virus nucleic acids; 3) In situ hybridization to identify latenly infected cells; 4) expression of virus proteins in herpes virus vectors and other routine molecular biology methods applied to virus diseases.

We would like to acknowledge Turner Biosystems for the grant of a TD 20/20 luminometer. For more information check their Luminometer Grants Website at this link:

http://www.luminometer.org/how-to-link.html

Recent Publications:

• Lahijani, R.S., E.W. Otteson, and S. St. Jeor. 1992. A possible role for nonsense suppression in the synthesis of a human cytomegalovirus 58-kDa virion protein. Virology, 186:309-312.
• Maciejewski, J., E. Bruening, E. Mocarski, N. Young, and S.C. St. Jeor. 1992. Infection of hematopoietic progenitor cells by human cytomegalovirus. Blood. 80:170-178.
• Maciejewski, J., E. Bruening, R. Donahue, S. Sellers, C. Carter, N. Young, and S. St. Jeor. 1993. Infection of mononucleated phagocytes with human cytomegalovirus. Virology. 195:327-336.
• Rowe, Joan E., Stephen C. St. Jeor, Jeffrey Riolo, Elmer W. Otteson, Martha C. Monroe, Thomas G. Ksiazek, Pierre E. Rollin, and Stuart T. Nichol. 1995. Coexistence of several novel hantaviruses in rodents indigenous to North America. Virology. 213:122-130.
• Henderson, Winnie W., Martha C. Monroe, Stephen C. St. Jeor, Wesley P. Thayer, Joan E. Rowe, C.J. Peters, and Stuart T. Nichol. 1995. Naturally occurring Sin Nombre virus genetic reassortants. Virology. 214:602-610.
• Otteson, Elmer W., Jeffrey Riolo, Joan E. Rowe, Stuart T. Nichol, Thomas G. Ksiazek, Pierre E. Rollin, & Stephen C. St. Jeor. 1996. Occurrence of hantavirus within the rodent population of northeastern California and Nevada. J Trop Med & Hygiene. 54(2):127-133.
• Levis, Silvana, Joan E. Rowe, Sergey Morzunov, Delia A. Enria, and Stephen St. Jeor. 1997. New hantaviruses causing HPS in Central Argentina. The Lancet, Apr 5:349(9057):998-9.
• Zhuravskaya, T., J.P. Maciejewski, D.M. Netski, F.R. Mackintosh, and S. St. Jeor. 1997. Spread of human cytomegalovirus after infection of human hematopoietic progenitor cells. Model of HCMV latency. Blood. 90:2482-2491.
• Levis, Silvana, Sergey P. Morzunov, Joan E. Rowe, Delia Enria, Noemi Pini, Gladys Calderon, Martha Sabattini, and Stephen St. Jeor. 1998. Genetic diversity and epidemiology of hantaviruses in Argentina. J. Inf. Disease. 177:529-38.
• Morzunov, Sergey P., Joan E. Rowe, Thomas G. Ksiazek, Clarence J. Peters, Stephen C. St. Jeor, and S. T. Nichol. 1998. Genetic analysis of the diversity and origin of hantaviruses in Peromyscus leucopus mice in N. A. J. Virology. 72:57-64.
• Boone, John D., Elmer W. Otteson, Pascal Villard, Kenneth C. McGwire, Joan E. Rowe, and Stephen St. Jeor. 1998. Ecology and demographics on hantavirus infections in rodent populations in the Walker River basin of Nevada and California. Am. J. Trop. Med. Hyg. 59(3):445-451.
• Prichard, Mark, N., Sanju Jairath, Mark E.T. Penfold, Stephen St. Jeor, Marlene C. Bohlman, and Gregory S. Pari. 1998. Identification of persistent RNA-DNA hybrid structures within the origin of replication of human cytomegalovirus. In Press. J. Virology.
• Netski, Dale, Brandolyn Ross, and Stephen St. Jeor. 1999. Sin Nombre virus pathogenesis in Peromyscus maniculatus. J. Virology. J. 73: 585-591.
• Feuer, Ralph, John D. Boone, Dale Netski, Sergey P. Morzunov, and Stephen C. St. Jeor. 1999. Temporal and spatial analysis of Sin Nombre virus quasispecies in naturally Infected rodents. J. Virology. November. Vol II. 73:9544-9554.
• Borucki, M.K., J.D. Boone, J.E. Rowe, M.C. Bohlman, E.A. Kuhn, R. DeBaca, and S.C. St. Jeor. 2000. The role of maternal antibody in natural infection of peromyscus maniculatus with sin Nombre Virus. J. Virology. 74:2426-2429.
• Boone, John D., Kenneth C. McGwire, Elmer W. Otteson, Pascal Villard, Peter Brussard, and Stephen St. Jeor. 2000. Remote sensing and geographic information system maps as indicators of the spatial pattern on Sin Nombre virus infections in deer mice (Peromyscus maniculatus). Emerging Infectious Disease. 6:248-258.
• Lobas, Jeffrey, M.D., Jeffrey J. Smith, M.D., and Mary D. Moore, M.D., Charles Grose, M.D., Joan E. Rowe, B.S., and Stephen C. St. Jeor, Ph.D.. 2000. Genetic analysis of Sin Nombre hantavirus in Iowa. Pediatric Infectious Disease J. 19:355-358.
• Garcia, J.B., S.P. Morzunov, S. Levis, J. Rowe, G. Calderon, D. Enria, M. Sabattini, M.J. Buchmeier, M.D. Bowen, and S.C. St. Jeor. 2000. Genetic Diversity of the Junin Virus in Argentina: Geographic and Temporal Patterns. Virology. 272:127-136.

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