St. Jeor, Ph.D.
of Microbiology and Immunology 320
School of Medicine
University of Nevada
Reno, NV 89557-0320
Office Phone: (775)
Lab Phone: (775) 784-1383
Howard Medical Sceinces, Room 208
Fax: (775) 327-2332
laboratory is interested in the
pathogenesis of virus diseases. In the overall area of virus pathogenesis
we are interested in the regulation of human cytomegalovirus latency and
the pathogenesis of New World Hantaviruses. Cytomegalovirus is a member
of the herpes group of viruses. It infects a high percentage of the human
population but is most common present as a latent virus infection. My
laboratory is interested in the mechanism by which the virus maintains
its latent infection and how its activation is regulated.
second area of interest is the pathogenesis of RNA viruses
which are present as epizootic diseases diseases. As a model we are investigating
the pathogenesis of New World Hantaviruses. There are several approaches
we use to understand the pathogenesis of these viruses in their natural
rodent hosts. We are studying natural infections by hantaviruses using
catch and release studies to investigate natural hantavirus infections.
We are also comparing factors associated with virus disease such as the
ability of the virus to induce specific inflammatory cytokines that contribute
to viral pathogenesis.
uses a variety of approaches to study virus pathogenesis including
the following: 1) nucleic acid sequencing; 2)RNAse protection assays and
real time PCR to quantitate virus nucleic acids; 3) In situ hybridization
to identify latenly infected cells; 4) expression of virus proteins in
herpes virus vectors and other routine molecular biology methods applied
to virus diseases.
would like to acknowledge Turner Biosystems for the grant of a TD 20/20 luminometer. For more information check their
Luminometer Grants Website at this link:
Lahijani, R.S., E.W.
Otteson, and S. St. Jeor. 1992. A possible role for nonsense suppression
in the synthesis of a human cytomegalovirus 58-kDa virion protein. Virology,
E. Bruening, E. Mocarski, N. Young, and S.C. St. Jeor. 1992. Infection
of hematopoietic progenitor cells by human cytomegalovirus. Blood. 80:170-178.
E. Bruening, R. Donahue, S. Sellers, C. Carter, N. Young, and S. St. Jeor.
1993. Infection of mononucleated phagocytes with human cytomegalovirus.
Rowe, Joan E., Stephen
C. St. Jeor, Jeffrey Riolo, Elmer W. Otteson, Martha C. Monroe, Thomas
G. Ksiazek, Pierre E. Rollin, and Stuart T. Nichol. 1995. Coexistence
of several novel hantaviruses in rodents indigenous to North America.
W., Martha C. Monroe, Stephen C. St. Jeor, Wesley P. Thayer, Joan E. Rowe,
C.J. Peters, and Stuart T. Nichol. 1995. Naturally occurring Sin Nombre
virus genetic reassortants. Virology. 214:602-610.
Otteson, Elmer W.,
Jeffrey Riolo, Joan E. Rowe, Stuart T. Nichol, Thomas G. Ksiazek, Pierre
E. Rollin, & Stephen C. St. Jeor. 1996. Occurrence of hantavirus within
the rodent population of northeastern California and Nevada. J Trop Med
& Hygiene. 54(2):127-133.
Levis, Silvana, Joan
E. Rowe, Sergey Morzunov, Delia A. Enria, and Stephen St. Jeor. 1997.
New hantaviruses causing HPS in Central Argentina. The Lancet, Apr 5:349(9057):998-9.
J.P. Maciejewski, D.M. Netski, F.R. Mackintosh, and S. St. Jeor. 1997.
Spread of human cytomegalovirus after infection of human hematopoietic
progenitor cells. Model of HCMV latency. Blood. 90:2482-2491.
Levis, Silvana, Sergey
P. Morzunov, Joan E. Rowe, Delia Enria, Noemi Pini, Gladys Calderon, Martha
Sabattini, and Stephen St. Jeor. 1998. Genetic diversity and epidemiology
of hantaviruses in Argentina. J. Inf. Disease. 177:529-38.
P., Joan E. Rowe, Thomas G. Ksiazek, Clarence J. Peters, Stephen C. St.
Jeor, and S. T. Nichol. 1998. Genetic analysis of the diversity and origin
of hantaviruses in Peromyscus leucopus mice in N. A. J. Virology. 72:57-64.
Boone, John D., Elmer
W. Otteson, Pascal Villard, Kenneth C. McGwire, Joan E. Rowe, and Stephen
St. Jeor. 1998. Ecology and demographics on hantavirus infections in rodent
populations in the Walker River basin of Nevada and California. Am. J.
Trop. Med. Hyg. 59(3):445-451.
Prichard, Mark, N.,
Sanju Jairath, Mark E.T. Penfold, Stephen St. Jeor, Marlene C. Bohlman,
and Gregory S. Pari. 1998. Identification of persistent RNA-DNA hybrid
structures within the origin of replication of human cytomegalovirus.
In Press. J. Virology.
Netski, Dale, Brandolyn
Ross, and Stephen St. Jeor. 1999. Sin Nombre virus pathogenesis in Peromyscus
maniculatus. J. Virology. J. 73: 585-591.
Feuer, Ralph, John
D. Boone, Dale Netski, Sergey P. Morzunov, and Stephen C. St. Jeor. 1999.
Temporal and spatial analysis of Sin Nombre virus quasispecies in naturally
Infected rodents. J. Virology. November. Vol II. 73:9544-9554.
Borucki, M.K., J.D.
Boone, J.E. Rowe, M.C. Bohlman, E.A. Kuhn, R. DeBaca, and S.C. St. Jeor.
2000. The role of maternal antibody in natural infection of peromyscus
maniculatus with sin Nombre Virus. J. Virology. 74:2426-2429.
Boone, John D., Kenneth
C. McGwire, Elmer W. Otteson, Pascal Villard, Peter Brussard, and Stephen
St. Jeor. 2000. Remote sensing and geographic information system maps
as indicators of the spatial pattern on Sin Nombre virus infections in
deer mice (Peromyscus maniculatus). Emerging Infectious Disease. 6:248-258.
Lobas, Jeffrey, M.D.,
Jeffrey J. Smith, M.D., and Mary D. Moore, M.D., Charles Grose, M.D.,
Joan E. Rowe, B.S., and Stephen C. St. Jeor, Ph.D.. 2000. Genetic analysis
of Sin Nombre hantavirus in Iowa. Pediatric Infectious Disease J. 19:355-358.
Garcia, J.B., S.P.
Morzunov, S. Levis, J. Rowe, G. Calderon, D. Enria, M. Sabattini, M.J.
Buchmeier, M.D. Bowen, and S.C. St. Jeor. 2000. Genetic Diversity of the
Junin Virus in Argentina: Geographic and Temporal Patterns. Virology.
For Dr. St Jeor's Publications In PubMed