Gray SOM Logo

Department of Pharmacology

University of Nevada School of Medicine

Reno, Nevada

Faculty Member
Image of Buxton Iain L.O. Buxton, Professor
Telephone:
Email:
(775) 784-1566 email
Fax: Location:
(775) 784-1620
Howard 216
About Dr. Buxton
Background Information on Iain Buxton:

Professor; D.Pharm., University of the Pacific, 1978. Receptor-signal transduction in cardiac and smooth muscle cells. Role of receptor-stimulated phosphoinosidtide metabolism; agonist-specific regulation of cyclic nucleotide action; role of adenyl purines in myometrial function and hormonal regulation of endothelial cell contractile factors.
Research Interests
The broad interests of our laboratory are those of receptor-signal transduction in mammalian systems. We approach our interests with modern biochemical and molecular methods that include intracellular imaging of events such as calcium release. One of our principal interests, for example, is the problem of premature delivery of babies. The signals that initiate contraction of the uterus at the time of labor are not known. We have recently described the contractile actions of adenyl purines on the smooth muscle of guinea pig uterus and find that the receptor that mediates the contraction of the tissue changes its coupling mechanism significantly during pregnancy in a fashion consistent with a role for these compounds in human parturition. The problem of premature delivery is a devastating human problem that takes its toll both in lives and dollars. We hope to contribute to an understanding of the onset of labor in order to help eliminate the problem of premature delivery.
Published Work
Selected Publications
  1. Shuttleworth, C.W., Weinert, J.S., Sanders, K.M., and Buxton, I.L. (1995). Detection of nitric oxide release from canine enteric neurons. J.Auton.Nerv.Syst. 56, 61-68.
  2. Zhang, L., Bradley, M.E., and Buxton, I.L. (1995). Inositolpolyphosphate binding sites and their likely role in calcium regulation in smooth muscle. Int.J.Biochem.Cell Biol. 27, 1231-1248.
  3. Buxton, I.L. (1996). HHMI awards [letter]. Science 271, 895
  4. Kuenzli, K.A., Bradley, M.E., and Buxton, I.L. (1996). Cyclic GMP-independent effects of nitric oxide on guinea-pig uterine contractility. Br.J.Pharmacol. 119, 737-743.
  5. Yang, S., Buxton, I.L., Probert, C.B., Talbot, J.N., and Bradley, M.E. (1996). Evidence for a discrete UTP receptor in cardiac endothelial cells. Br.J.Pharmacol. 117, 1572-1578.
  6. Smith, A.D., Cheek, D.J., Buxton, I.L., and Westfall, D.P. (1997). Competition of adenine nucleotides for a 1,3-[3H]-dipropyl-8- cyclopentylxanthine binding site in rat vas deferens. Clin.Exp.Pharmacol.Physiol. 24, 492-497.
  7. Bradley, K.K., Buxton, I.L., Barber, J.E., McGaw, T., and Bradley, M.E. (1998). Nitric oxide relaxes human myometrium by a cGMP-independent mechanism. Am.J.Physiol. 275, C1668-C1673
  8. Kuenzli, K.A., Buxton, I.L., and Bradley, M.E. (1998). Nitric oxide regulation of monkey myometrial contractility. Br.J.Pharmacol. 124, 63-68.
  9. Zhang, L. and Buxton, I.L. (1998). Measurement of phosphoinositols and phosphoinositides using radio high- performance liquid chromatography flow detection. Methods Mol.Biol. 105:47-63, 47-63.
  10. Oxhorn, B.C., Cheek, D.C. and Buxton, I.L.O. (2000) On the role of nucleotides and nucleosides in the regulation of blood flow. AACN Clinical Issues May 11(2): 241-251.
  11. Buxton, I.L.O. , Crow, W. and Mathew, S.O. (2000) Regulation of uterine contraction: Mechanisms in preterm labor. AACN Clinical Issues May 11(2): 271-282.
  12. Buxton, I.L.O., Kaiser, R.A , Malmquist, N.A. and Tichenor, S. (2001) NO-induced relaxation of Labouring and Non-labouring human myometrium is not mediated by cGMP. Br. J. Pharmacol. 134: 206-214.
  13. Buxton, I.L.O., Kaiser, R.A., Oxhorn, B.C. and Cheek, D.J. (2001) Evidence Supporting the Nucleotide Axis Hypothesis: ATP Release and Metabolism by Coronary Endothelium. Am. J. Physiol: Heart and Circulatory 281:H1657-1666.
  14. Anzinger, J., Malmquist, N. A., Gould, J. and Buxton, I. L. O. (2001) Secretion of a nucleoside diphospho kinase (Nm23-H2) by cells from human breast, colon, pancreas and lung tumors. Proc. West Pharmacol. Soc. 44:61-63.
  15. Tangredi, J.F. and Buxton, I.L.O. (2001) Hypertension as a complication of topical testosterone therapy. Annals of Pharmacotherapy 35:1205-1207.
  16. Tichenor, S., Malmquist, N.A. and Buxton, I.L.O. (2001) Actions of S-nitroso N-acetyl penicillamine and 3-morpholinosydonimine may involve disparate signaling pathways in myometrial smooth muscle. Proc. West Pharmacol. Soc. 44:53-56.
  17. Malmquist, N.A., Anzinger, J.J., Hirzel, D. and Buxton, I.L.O. (2001) Ellagic acid inhibits nucleoside diphosphate kinase-b activity. Proc. West Pharmacol. Soc. 44: 57-59.
  18. Kaiser, R.A. and I.L.O. Buxton (2001) Endothelium-dependent, MRS2179-independent actions of uridine 5’-triphosphate in guinea pig aorta. Proc. West Pharmacol. Soc. 44:49-51.
  19. Oxhorn, B.C., Wadia, R. and Buxton, I.L.O. (2001) Caspase-3 is localized to endothelial caveolar domains. Proc. West Pharmacol. Soc. 44:45-48.
  20. Kaiser, R.A. and Buxton, I.L.O. (2002) Nucleotide-mediated relaxation in guinea pig aorta: Selective inhibition by MRS2179. Br. J. Pharmacol. 135:537-545.
  21. Oxhorn, B.C. and Buxton, I.L.O. (2002) Isolation and characterization of large numbers of endothelial cells for studies of caveolar signaling. Journal of Microvascular Research 64:302-315.
  22. Tichenor, S.D., Buxton, I.L.O., Johnson, P., O’Driscoll, K. and Keef, K.D. (2002) Excitatory motor innervation in the canine rectoanal region: Role of changing receptor populations. Br. J. Pharmacol. 137:1321-1329.
  23. Kaiser, R.A., Andrews, G., Oxhorn, B.C. and Buxton, I.L.O. (2002) Functional compartmentation of endothelial P2Y receptor signaling. Circulation Research 91:292-299.
  24. Mazzone, J.N., Kaiser, R.A. and Buxton, I.L.O. (2002) Calcium-Activated potassium channel expression in human myometrium: Effect of pregnancy. Proc. West Pharmacol. Soc. 45:184-186.
  25. Buxton, I.L.O. (2003) Invited Review: What is it about the uterus anyway? Proc. West Pharmacol. Soc. 46: 1-8.
  26. Mazzone, J and Buxton, I.L.O. (2003) Changes in small conductance potassium channel expression in human myometrium during pregnancy measured by RT-PCR. Proc. West Pharmacol. Soc. 46: 74-77.
  27. Oxhorn, B.C. and Buxton, I.L.O. (2003) Caveolar compartmentation of caspase-3 in cardiac endothelial cells. Cellular Signalling 15:489-496.
  28. Tichenor, S. and Buxton, I.L.O. (2003) Dissociation of cGMP and relaxation in myometrial smooth muscle: Effects of S-Nitroso N-acetylpenicillamine and 3-morpholiosyndonimine. Cellualr Signalling 15:763-772
  29. Buxton, N.D., Kaiser, R.A. and Buxton, I.L.O. (2003) Vascular actions of the polyphenolic catechin gallate EGCG: Endothelium-Dependent Contraction and Relaxation. Proc. West Pharmacol. Soc. 46:37-38.
  30. Buxton, I.L.O. (2004) Regulation of uterine function: A biochemical conundrum in the regulation of smooth muscle relaxation. Molecular Pharmacology 65:1051-1059
  31. Kaiser, R.A. and Buxton, I.L.O. (2004) Nucleotides in the blood stream. Proc. West. Pharmacol. Soc. 47:5-15.
Other Information
Lab Personnel
The Lab Picture

 
 

http://www.medicine.nevada.edu/dept/Pharmacology/display.asp?ID=

All email addresses on this Web site are NOT links in an effort to reduce spam. Thank you.

N Home http://www.unr.edu/        University of Nevada, Reno

Maintained by: Janet K. Holmes

Email: jholmes@med.unr.edu

Last Modified: September 6, 2005->->->->
   
Pharmacology Home http://www.medicine.nevada.edu/dept/Pharmacology/main.htm
Pharmacology Courses http://www.medicine.nevada.edu/dept/Pharmacology/courses.asp
COBRE http://www.medicine.nevada.edu/dept/Pharmacology/COBRE/Default.asp
Nevada Transgenic Center http://www.medicine.nevada.edu/dept/pharmacology/transgenic/
Faculty http://www.medicine.nevada.edu/dept/Pharmacology/faculty_listing.asp
Graduate Programs http://www.medicine.nevada.edu/dept/basicscience.asp
CMPP Graduate Program http://www.medicine.nevada.edu/dept/cmpp/index.htm
Graduate School http://www.vpr.unr.edu/grad2/
Grant Forms http://www.medicine.nevada.edu/dept/Pharmacology/grants.htm
School of Medicine http://www.medicine.nevada.edu/
UNR Home http://www.unr.edu/content/
ASPET http://www.aspet.org/