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DIANA McCLOSKEY, Ph.D.
Research Assistant Professor
Ph.D., King's College, London, 1999
Location: Manville 8C
E-mail: dmccloskey medicine.nevada.edu
Tel: (775) 784-1821
Fax: (775) 784-1620
Research Interests
The molecular mechanism of Cl - channel regulation is an important issue for understanding how cells regulate their volume and for understanding structure/function relationships of ion channel properties in general. We previously proposed ClC-3, a member of the ClC superfamily of voltage-dependent Cl - channels, as a molecular candidate for volume-sensitive outwardly rectifying anion channels (VSOAC) in cardiac and smooth muscle cells. VSOACs play a potentially important role in cardiac physiology and pathophysiology including regulation of cell volume, action potential duration, proliferation, apoptosis and involvement in myocardial ischemia and hypertrophy. Using electrophysiological methods (whole-cell patch clamp) my research is focused on looking at the functional characterization and regulation of VSOACs as well as ClC-3 expressed currents.
View the publications of Dr McCloskey on PubMed
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