Center of Biomedical Research Excellence (COBRE)

Scope

The scope of the COBRE Research Program includes five separate research projects and three support core facilities to study the role of chloride channels in normal cardiac function and disease.

Areas of Study

1. Single Proteins and Cells
2. Gene Transcription
3. Animal Models of Cardiac Disease
4. Genetics and Cardiovascular Disease

Objectives

1. Comprehensive research program to study the function and role of chloride channel transport proteins in cardiovascular disease.
2. Promote new collaborative interactions between research investigators at University of Nevada School of Medicine (UNSOM).
3. Promote the development of a new cadre of young research investigators at UNSOM.
4. Establish new state-of-art biomedical technologies, including genomic and transgenic animal facilities, that will benefit other existing research programs at UNSOM.

Participants

Joseph Hume, Ph.D., Pharmacology, - Program Director
Diana McCloskey, Ph.D., Pharmacology
Ilya Yamboliev, Ph.D., Pharmacology
Fiona Britton, Ph.D., Physiology & Cell Biology
Dayue Duan, M.D. Ph.D., Pharmacology
Maria Valencik, Ph.D., Biochemistry
Dean Burkin, Ph.D., Pharmacology
Gregory Pari, Ph.D., Microbiology
William Hatton, Ph.D., Pharmacology
Christopher von Bartheld, M.D. Physiology & Cell Biology
Normand Leblanc, Ph.D., Pharmacology
William Welch, Ph.D., Biochemistry
Kathy Schegg, Ph.D., Biochemistry

Schematic of Cardiac Chloride Channels

Cardiac anion channels, transport and exchange proteins and their intracellular signaling pathways
(from Hume et al., Physiol. Rev. 80: 31-81, 2000)

Contact: Center of Biomedical Research Excellence
Department of Pharmacology MS/318
University of Nevada
School of Medicine
Reno, NV 89557-0270 USA

Supported by the National Center for Research Resources (NCRR)

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University of Nevada, Reno
Last updated: 4/16/07