Gary K. Shen, M.D.

University of Nevada School of Medicine
Department of Surgery
2040 W. Charleston Blvd, Suite 302
Las Vegas, NV 89102
702-671-2339
Fax: 702-385-9399
E-mail: gshen@med.unr.edu

Curriculum Vitae

Education

University of California, Berkeley, Regent’s Scholar
Degree: BA, Physics, May 1984

University of Rochester School of Medicine and Dentistry,
Rochester, New York
Degree: MD, May 1988

Post-Graduate Training:

Internship/Residency: University of Arizona - Tucson Hospitals Surgery
Residency Program, 1988-1995
Chairman, Department of Surgery: Bruce E. Jarrell, M.D.
Residency Program Director: Charles W. Putnam, M.D.

Fellowship: Multi-Organ Transplant Fellowship, Stanford University
Medical Center, 1995-1996
Director: Donald C. Dafoe, M.D.

Faculty Positions:

Associate Professor of Surgery, Chief, Division of Transplantation, University of Nevada School of Medicine, Las Vegas, Nevada, March 2000, Tenured, 2006

Assistant Professor of Surgery, Albany Medical College, Albany, New York, July 1996-Feb 2000

Post-graduate Research:

Department of Surgery and Research Services, Veteran Affairs
Medical Center, Tucson, Arizona, 1990-1992
Preceptors: Charles F. Zukoski, M.D.
David W. Montgomery, Ph.D.

Research Areas:
Immune function of pituitary hormones
Immunosuppressive cyclic peptides
Lymphokine effects on the neuroendocrine system

Publications:

1. Echo A, Hovsepian RV, Shen GK. Localized cecal zygomycosis following renal transplantation. Transplantation Infectious Disease 2005, 7: 68-70.
2. Hedges JC, Hovsepian RV, Niles PA, Shen GK. Whole organ pancreas recovery using ultrasonically activated shears. Transplantation 2005, 79: 735.
3. Shen GK, Recicar JF, Salisbury JA, Browder TD, Niles PA. Correction of base deficits in deceased organ donors: effects on immediate renal allograft function. Transplantation Proceedings 2004, 36: 2559-2561.
4. Shen GK, Niles PA, Richardson KE. Presumed consent: the case of the “John Doe” donor. Transplantation 2003, 77: 792-793.
5. TNF-?, IL-6, TFN-?, and IL-10 gene expression polymorphism and the IL-4 receptor ? -chain variant Q576R: effects on renal allograft outcome. Hahn A, Kaston-Jolly JC, Constantino D, Graffunder E, Sighn TP, Shen GK, Conti DJ. Transplantation 2001, 72: 660-665.
6. Failure of ganciclovir prophylaxis to completely eradicate CMV disease in renal transplant recipients treated with intense anti-rejection immunotherapy. Isenberg AL, Shen GK, Singh TP, Hahn A, Conti DJ. Clin Transplant 2000, 14: 193-198.
7. Failure of ganciclovir prophylaxis of primary cytomegalovirus disease in immunologic high-risk recipients. Conti DJ, Isenberg A, Shen GK, Hahn A, Singh TP. Transplant Proc 1998, 30: 1314-5.
8. Causes of long-term renal allograft failure: no chronic rejection at three years. Shen GK, Isenberg Al, Singh TP, Hahn A, Conti DJ. Transplant Proc 1998, 30:1205-1206.
9. Selective Cellcept therapy in high-risk renal transplant recipients. Isenberg A, Singh TP, Shen GK, Freed BM, Conti DJ. Transplant Proc 1998, 30: 1188-9.
10. Shen GK, Salvatierra Jr O, Dafoe DC, and Alfrey EJ. Use of split horseshoe kidney for transplantation. Surgery 1998, 123: 475-477.
11. Shen GK, Alfrey EJ, Knoppel CL, Dafoe DC, and Scandling JD. Eradication of cytomegalovirus reactivation disease using high dose acyclovir and targeted ganciclovir in kidney and kidney/pancreas transplantation. Transplantation 1997, 64: 931-933.
12. Conti DJ, Shen GK, Singh T, Isenberg A, and Freed BM. Ganciclovir prophylaxis of cytomegalovirus disease. Transplant Proc 1997, 29: 804-806.
13. Lee CM, Scandling JD, Shen GK, Salvatierra O, Dafoe DC, and Alfrey EJ. The kidneys that nobody wanted: Support for the utilization of expanded criteria donors. Transplantation 1996, 62: 1832-1841.
14. Shen GK, Tsen AC, Hunter GC, Ghory MJ, and Rappaport W. Surgical treatment of symptomatic biliary stones in patients with cystic fibrosis. Am Surg 1995, 61: 814-819.
15. Montgomery DW, Shen GK, Ulrich ED, and Zukoski CF. Immunomodulation by didemnins: invertebrate marine natural products. Ann NY Acad Sci 1994, 712: 301-304.
16. Montgomery DW, Shen GK, Ulrich ED, Steiner LL, Parrish PR, and Zukoski CF. Human thymocytes express a prolactin-like messenger ribonucleic acid and synthesize bioactive prolactin-like proteins. Endocrinology 1992, 131: 3019-3026.
17. Shen GK, Montgomery DW, Ulrich ED, Mahoney KR, and Zukoski CF. Up-regulation of prolactin gene expression and feedback modulation of lymphocyte proliferation during acute allograft rejection. Surgery 1992, 112: 387-394.
18. Shen GK, Zukoski CF, and Montgomery DW. A specific binding site in Nb2 node lymphoma cells mediates the effects of didemnin B, an immunosuppressive cyclic peptide. Int J Immunopharm 1992, 14: 63-73.
19. Shen GK, and Rappaport W. Control of intra-abdominal hemorrhage with temporary packing. Surg Gynecol Obstet 1992, 174: 411-413.
20. Shen GK, Wong R, Daller J, Melcer S, Tsen A, Awtrey S, and Rappaport W. Does the retrocecal position of the vermiform appendix alter the clinical course of acute appendicitis? A prospective analysis. Arch Surg 1991, 126: 569-570.
21. Shen GK, Carnahan W, and Rappaport W. The varied presentation of retroperitoneal appendicitis. Contemp Surg 1990, 37: 9-13.

Abstracts:

1. Perforated intestinal zygomycosis: an unusual complication following renal transplantation and immunosuppression. Echo A, Hovsepian RV, Shen GK. Presented at the Southwestern Surgical Congress, El Paso, April 2005.
2. Correction of base deficits in deceased organ donors facilitates fluid management and improves immediate renal allograft function. Shen GK, Recicar JF, Salisbury JA, Browder TD, Niles PA. Presented at the American Transplant Congress, Boston, May 2004.
3. Combination therapy in the organ donor: aggressive intravenous fluid administration with diuretics. Niles PA, Crossen H, Shen GK. Submitted to the Association of Organ Procurement Organizations annual meeting, June 2004.
4. 2-D axisymmetric finite difference modeling of thermistor probe heating on the kidney. Brown F, Boehm R, Shen GK. Presented at the ASME 2003 Heat Transfer Conference, Las Vegas, 2003.
5. Use of ultrasonically activated shears facilitates whole organ pancreas recovery. Shen GK, Hovsepian RV, Miyake BK, Niles PA. Presented at the Congress of International Pancreas and Islet Transplant Association, July 2003.
6. Correction of base deficits improves fluid resuscitation in deceased organ donors. Recicar JF, Niles PA, Shen GK. Presented at NATCO Annual Meeting, New Orleans, July 2003.
7. Iliac fossa compartment syndrome – complication of wound closure after renal transplantation: report of a case. Reese LM, Edwards JA, Shen GK. Presented at the Southwestern Surgical Congress, Tucson, April 2003.
8. Superior outcome of arteriovenous grafts for hemodialysis – a single center experience. Hovsepian RV, Jones SR, Shen GK. Presented at the Southwestern Surgical Congress, Tucson, April 2003.
9. Modified ureteroneocystostomy for duplicate ureters in renal transplantation: report of two cases. Dwinell SC, Reese LM, Shen GK. Presented at the Southwestern Surgical Congress, Tucson, April 2003.
10. Shen GK, Precht A, Naviaux R, Barshop B, Hart M, Khanna A. First report of living related liver transplant for pyruvate carboxylase deficiency. Presented at the XIX Congress of the International Transplantation Society, August 2002.
11. Finite difference modeling of thermistor probe heating on the kidney. Brown F, Boehm R, Shen GK. Presented at the 2002 International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences, Las Vegas, June 2002.
12. Short-term monitoring of perfusion in transplanted organs. Brown F, Boehm R, Shen GK. Presented at the Nevada Biomedical Research and Education Conference, Las Vegas, March, 2001.
13. A novel intervention to increase organ donation rates. Conti DJ, Singh TP, Shen GK, Taft F. Presented at the American Society of Transplantation, May, 2000.
14. Effect of cytokine gene promoter polymorphisms on renal allograft outcome. Hahn AB, Kasten-Jolly JC, Constantino DM, Singh TP, Shen GK, Conti DJ. The American Society of Histocompatibility and Immunogenetics, New Orleans, October 1999.
15. Effect of cytokine gene promoter polymorphisms on pre-transplant alloantibody production. Hahn AB, Kasten-Jolly JC, Constantino DM, Allen M, Singh TP, Shen GK, Conti DJ. The American Society of Histocompatibility and Immunogenetics, New Orleans, October 1999.
16. Increasing living donor pool for renal transplantation: paired donation vs. cadaver exchange. Shen GK, Singh TP, Funk D, Conti DJ. The American Society of Transplantation, Chicago, May 1999.
17. Early acute rejection and late graft loss: an analysis of paired cadaver kidneys. Conti DJ, Isenberg AI, Hahn A, Shen GK, and Singh TP. The American Society of Transplant Surgeons, Chicago, May 1998.
18. Failure of ganciclovir prophylaxis of CMV disease in immunologic high-risk recipients. Isenberg AI, Shen GK, Singh TP, Hahn A, and Conti DJ. The Surgical Infection Society, New York City, May 1998.
19. Shen GK, Isenberg AL, Singh TP, Freed BM, Lempert N, and Conti DJ. Causes of long term renal allograft failure- no chronic rejection at three years. The International Congress on Immunosuppression, Orlando, December 1997.
20. Isenberg A, Singh TP, Shen GK, Freed B, and Conti DJ. Selective Cellcept therapy in high-risk renal transplant recipients. The International Congress on Immunosuppression, Orlando, December 1997.
21. Conti DJ, Shen GK, Isenberg A, and Singh TP. Failure of ganciclovir prophylaxis of primary CMV disease in immunologic high-risk recipients. The International Congress on Immunosuppression, Orlando, December 1997.
22. Singh TP, Isenberg A, Shen GK, Freed BM, and Conti DJ. Improved graft survival in retransplant recipients: an analysis of paired cadaver kidneys. American Society of Transplant Surgeons, Chicago, May 1997.
23. Lee CM, Scandling JD, Shen GK, Knoppel CL, Dafoe DC, and Alfrey EJ. The kidneys that nobody wanted. American Society of Transplant Physicians, Dallas, May, 1996.
24. Shen GK, Alfrey EJ, Knoppel CL, Dafoe DC, and Scandling JD. Eradication of CMV reactivation disease: prophylaxis using high dose acyclovir and preemptive ganciclovir in kidney and kidney/pancreas transplantation. American Society of Transplant Physicians, Dallas, May, 1996.
25. Shen GK, Alfrey EJ, and Dafoe DC. Use of dual cadaveric kidneys for transplant into a single recipient. Western Association of Transplant Surgeons, Seattle, February, 1996.
26. Montgomery DW, Shen GK, Ulrich ED, and Zukoski CF. Immunomodulation by didemnins: invertebrate marine natural products. New York Academy of Sciences, New York, May, 1993.
27. Shen GK, Montgomery DW, and Zukoski CF. Up-regulation of prolactin gene expression during allograft rejection: possible role of IL-1 and IL-6. First prize, Davis & Geck resident research award, University of Arizona, May, 1992,
28. Shen GK, Montgomery DW, Ulrich ED, Mahoney KR, and Zukoski CF. Up-regulation of prolactin gene expression and feedback modulation of lymphocyte proliferation during acute allograft rejection. Society of University Surgeons, Cincinnati, February, 1992.
29. Shen GK, Zukoski CF, and Montgomery DW. Identification of a binding site for didemnin B, an immunosuppressive peptide, in normal lymphocytes and Nb2 lymphoma cells. First prize, Davis & Geck resident research award, University of Arizona, May, 1991.
30. Shen GK, Allen RC, Hunter GC, Zuniga RE, and Rappaport W. Peri-operative myocardial infarction in patients undergoing non-vascular procedures. Southwestern Surgical Congress, Tucson, April, 1994.
31. Shen GK, Montgomery DW, and Zukoski CF. Identification of didemnin B binding sites on Nb2 node lymphoma cells. Federation of American Society of Experimental Biology, Atlanta, April, 1991.
32. Shen GK, and Rappaport W. Control of non-hepatic intra-abdominal hemorrhage with temporary packing. Southwestern Surgical Congress, Las Vegas, April, 1991.

Invited Forums:

Transplantation Innovations and Management Strategies. An Educational Initiative for Nephrologists. Session speaker. Las Vegas, March 2004.

Developing perspectives on the use thymoglobulin in renal transplantation. Las Vegas, April 2003.

Dialysis &Transplantation CME seminar, Las Vegas, September 2002: Management of dialysis access complications.

Session chairman, Kidney Organ Donation I, American Transplant Congress, Washington DC, April 2002

Impact of immunosuppression on long-term kidney transplant outcomes. Del Mar, California, February 2002.

Emerging Pathogens and Interventions for Clinicians Advisory Board, San Diego, January 2002.

Medical Explorers Program, University Medical Center, Las Vegas, March 2001: Career in transplantation.

Emerging Pathogens and Interventions for Clinicians Advisory Board, Santa Barbara, January 2001.

University Medical Center adult health education program, Las Vegas, June 2000: Transplant issues that patients and their families face.

High School Medical Scholar Program, Reno, June 2000: Issues in organ transplantation and donation.

Dialysis & Transplantation CME Seminar, Las Vegas, May 2000: Immunosuppressive drugs for renal transplantation.

Med-Surg Grand Round, VA Medical Center, Reno, Nevada, May 2000: Overview of pancreas transplantation.

Medical Explorer Program, University Medical Center, Las Vegas, March 2000: Career in transplantation.

The 1999 Upstate New York Transplant Meeting, Syracuse, Oct 1999: Lymphoceles after renal transplantation.

Endocrinology grand round, Albany Medical Center, March 1999: Prospects for islet cell transplantation.

Invited speaker, Nanking Medical Center, Nanking, China, January 1999: Current status of kidney and pancreas transplantation.

Invited speaker, First Medical College, Chendu, China, January 1999: Organ procurement, distribution, and preservation in the United State.

Nephrology grand round, Albany Medical Center, April 1998: Simultaneous pancreas kidney transplantation for diabetic patients with ESRD.

Future Trends in Transplantation, Albany, NY, November 1997: Trends in pancreatic and islet cell transplant.

CME course, Nathan Littore Hospital, Gloversville, NY, July 1997: Organ donation in the United States.

Surgery grand round, Albany Memorial Hospital, Albany, NY, November 1996: Pancreas transplant: current status and updates.

Phase III renal transplant advisory meeting, Boston, MA, May 1997: Prograf in renal transplantation.

Research Protocols:

Principal investigator:

Low dose cyclosporine or tacrolimus in sirolimus based immunosuppression without induction for de novo renal transplant recipients. Wyeth Pharmaceutical sponsored study, 2005.

Combination myfortic and sirolimus immunosuppression in low risk renal transplant recipients. Novartis Pharmaceutical sponsored study, 2005.

Thymoglobulin antibody immunosuppression in living donor recipients registry, 2003

Simulect after living donor renal transplant registry, 2002

Fenoldopam for delayed graft function after renal transplantation, 1999.

Thermal dilution probe for monitoring renal blood flow after transplantation, 1998.

Abbott IMX Assay for Tacrolimus, 1996.

Co-investigator:

Use of MRI flow characteristics to predict renal allograft dysfunction. Principal Investigator: Michael Gach, Ph.D., Nevada Cancer Institute, NIH sponsored.

Thermal dilution probe to measure renal blood flow after transplantation, 2000.

An open label, randomized, multicenter study to evaluate the safety and efficacy of Zenapax in combination with Cellcept, corticosteroids and standard or reduced dose Prograf for the prevention of acute rejection in primary renal allograft recipients, 1999.

A clinical experience with Abbott cyclosporine in de novo renal transplant subjects, 1999.

A three-year, randomized, multicenter, double-blind, double-dummy, parallel group study of the efficacy and safety of SDZ RAD tablets versus mycophenolate mofetil as part of triple immunosuppressive therapy in de novo renal transplant recipients, 1998.

A comparative study of the effect and equivalence of sirolimus oral liquid versus sirolimus tablets, administered concomitantly with cyclosporine and corticosteroids in renal allograft recipients, 1997.

Oral valaciclovir safety, pharmacokinetics and suppression of cytomegalovirus infection and disease in renal allograft recipients, 1997.

A double-blind, comparative study of the effect of two dose levels of sirolimus versus azathioprine, administered concomitantly with standard immunosuppressive therapy in renal allograft recipients, 1996.

A randomized, double-blind comparative study of safety of intravenous mycophenolate mofetil and oral mycophenolate mofetil in renal transplant recipients in the immediate post-operative period, 1996.

A 6-day open-label pharmacokinetics bioavailability evaluation of mycophenolic acid when switching from intravenous mycophenolate mofetil to oral mycophenolate mofetil in renal transplant recipients in the immediate post-operative period, 1996.

Committees and Appointments:

Promotion and Tenure Committee, University of Nevada, Reno, 2006
State Councilor, Southwestern Surgical Congress, 2004
Kidney/pancreas committee region 5 representative, the United Network of Organ Sharing, 2003
Med-Associates Practice Plan At-large Board Member, 2002.
Medical School Faculty Council, 2002.
Abstract Review Committee, American Transplant Congress, 2001-2002.
Medical Director of Nevada Donor Network, 2000.
Kidney/pancreas committee region 9 representative, the United Network of Organ Sharing, 1997-1999
Pharmacy and Therapeutics committee, Albany Medical Center, 1997- 2000
Antibiotics Committee, Albany Medical Center, 1996- 2000
Transplant Quality Improvement Team, Albany Medical Center, 1998-2000

Organizations:
Alpha Omega Alpha Honor Medical Society
American Society of Transplant Surgeons, 1996
Fellow of American College of Surgeons, 1999
American Society of Transplantation, 2000
American Medical Association, 1988

Certifications:

Certificate, American Board of Surgery
State of California medical license
State of Nevada medical license