John R. Gosche, MD, PhD
Chief, Division of Pediatric Surgery, Professor of Surgery, University of Nevada School of Medicine

Department of Surgery
University of Nevada School of Medicine
2040 West Charleston Blvd., Suite 601
Las Vegas, Nevada 89102
Telephone (702) 671- 2373

Curriculum Vitae

John R. Gosche, MD, PhD

Educational Background:

College: University of South Florida, Tampa FL BA in Biology, 1981
University of South Florida, Tampa FL BA in Chemistry 1981

Professional School: MD University of South Florida College of Medicine 1985

Graduate Study: PhD in Cardiovascular Physiology
University of Louisville, Louisville KY 1992

Postgraduate Training:
Dept. of Surgery, University of Louisville, intern in general surgery ‘85-‘86
Dept. of Surgery, Univ. of Louisville, resident, general surgery, ‘86-’88, ‘90-’92
Columbus Children’s Hospital, Ohio State University, resident, pediatric surgery,
’92-‘94

Honors and Awards:
Faculty-Staff Student Scholarship, USF College of Medicine 1981-1985
Outstanding Medical Graduate, USF College of Medicine 1985
Alpha Omega Alpha National Medical Honor Society 1985
Research Fellowship Award, Center of Excellence in Applied
Microcirculatory Research, University of Louisville 1988-1990
Annual Essay Award for the Best Basic Science Paper, Presented at the
Association of VA Surgeons, 14th Annual Surgical Symposium 1990
Charles M. Edelen Award for the Best Publication by a Surgical Resident
University of Louisville, Department of Surgery 1991
Top Graduating PhD Student,
University of Louisville School of Medicine 1992
The Robert H. Bartlett Award for Best Abstract Presentation,
8th Annual ELSO Conference 1997
“ Top Docs”, Connecticut Magazine, February 2001 2001

Specialty Certification:
American Board of Surgery, Pediatric Surgery (certificate # 661)
American Board of Surgery, General Surgery (certificate # 39426)

Licensure: Mississippi (# 17266), Nevada (#12275)

Professional Memberships:
Association for Academic Surgery
Fellow, American College of Surgeons
Fellow, American Academy of Pediatrics, Surgical Section
American Pediatric Surgical Association
American Physiological Society
American Heart Association
Society of University Surgeons

Academic Appointments:
Assistant Professor of Surgery and Pediatrics
Yale University School of Medicine
New Haven, CT 07/01/1994-06/30/2000

Associate Professor of Surgery and Pediatrics
Yale University School of Medicine
New Haven, CT 07/01/2000-06/30/2001

Associate Professor of Surgery
Associate Professor of Physiology and Biophysics
Assistant Professor of Pediatrics
Chief, Division of Pediatric Surgery
University of Mississippi Medical Center
Jackson, MS 07/01/2001-12/29/2006

Professor of Surgery
Chief, Division of Pediatric Surgery
University of Nevada School of Medicine
Las Vegas, NV 01/01/2007- present

Other Experience/Committees:

- Surgical Director, ECMO program, Yale-New Haven Hospital, New Haven, CT., 7/1994-6/2001
- Director, Pediatric Surgical Research Laboratory, Yale University School of Medicine, New Haven, CT, 7/1994-6/2001
- Pediatric Trauma Director, Yale-New Haven Children’s Hospital, New Haven, CT, 7/1998-6/2001
- Thesis Committee, Yale University, Department of Surgery, 1997-1999
- Program Committee, Surgical Section of the American Academy of Pediatrics, 1998- 2000
- Surgical Endoscopy Assurance Committee- Yale-New Haven Hospital, 1998-2001
- OR Formulary Subcommittee- Yale-New Haven Hospital, 1999-2001
- Membership Committee, Association for Academic Surgery, 2000-2001
- Connecticut Pediatric Trauma Subcommittee , 2000-2001
- Program Committee, American Pediatric Surgical Association, 2003-2005
- Publications Committee, Surgical Section of the American Academy of Pediatrics, 2003-2005
- Chair, Pediatric Trauma Committee, University of Mississippi Medical Center, 2004-present
- Chair, Batson OR Subcommittee, University of Mississippi Medical Center, 2004-present
- Medical Director for Surgical Services for the Blair E. Batson Hospital for Children, 2005-present
- Vice Chair, Publications Committee, Section on Surgery, American Academy of Pediatrics, 2005
- Vice Chair, Program Committee, American Pediatric Surgical Association, 2006-2007
- Chair, Publications Committee, Section on Surgery, American Academy of Pediatrics, 2006
- Institutional grant review committee, American Cancer Society, University of Mississippi Medical Center, 2006
- Membership Committee, The Society of University Surgeons, 2006-2009
- Ad Hoc reviewer: Journal of Pediatric Surgery, Journal of Surgical Research, American Journal of Surgery, Journal of Pathology

Publications:
1. Gosche JR, Sharpe NJ, Larson GM. Colonoscopic decompression of pseudoobstruction of the colon. Am Surg 55:111-115, 1989.
2. Gosche JR, Garrison RN, Harris PD, Cryer HM. Absorptive hyperemia restores intestinal blood low during Escherichia coli sepsis in the rat. Arch Surg 125:1573-1576, 1990.
3. Gosche JR, Garrison RN. Prostaglandins mediate the compensatory responses to hemorrhage in the small intestine of the rat. J Surg Res 50:584-588, 1991.
4. Flynn WJ, Gosche JR, Garrison RN. Intestinal blood flow is restored with glutamine or glucose suffusion after hemorrhage. J Surg Res 52:499-504, 1992.
5. Gosche JR, Harris PD, Garrison RN. Intestinal microvascular responses during low-flow states in adult and suckling rats. Am J Physiol 264:G447-G453, 1993.
6. Gosche JR, Spain DA, Garrison RN, Lüebbe AS, Cryer HG. Differential microvascular response to cyclooxygenase blockade in the rat small intestine during acute bacteremia. Shock 2:408-412, 1994.
7. Besner GE, Qualman SP, Gosche JR. Identification of a duplicated undescended testicle (polyorchia): An unexpected benefit of laparoscopic localization. J Laparoendoscopic Surg 6:S107-S114, 1996.
8. McCarthy DW, Besner GE, Gosche JR, Qualman SP, Chan DP, Olson TA. Retroperitoneal yolk sac tumor with spinal cord compression and intracardiac extension. Int J Pediatr Hematol Oncol 3:157-161, 1996.
9. Gosche JR, Harris PD, Garrison RN. Age-related differences in intestinal arteriolar response to venous pressure elevation in the rat. Microcirculation 3:395-400, 1996.
10. Fields JM, Schwartz DS, Gosche J, Keller MS. Idiopathic bilateral anterior mediastinal abscesses. Pediatr Radiol 27:596-597, 1997.
11. Kalyanpur A, Schwartz DS, Fields JM, Reyes-Mugica M, Keller MS, Gosche J. Renal medullary carcinoma in a white adolescent. Am J Roentgenol 169:1037-1038, 1997.
12. Roddy, SP, Cohn SM, Moller BA, Duncan CA, Gosche JR, Seashore JH, Touloukian RJ. Minimal head trauma in children revisited: Is routine hospitalization required? Pediatrics 101:575-577, 1998.
13. Coppola C, Au-Fliegner M, Gosche JR. Endothelin-1 pulmonary vasoconstriction in rats with diaphragmatic hernia. J Surg Res 76:74-78, 1998.
14. Au-Fliegner M, Salami S, Gosche JR. Pulmonary arterioles from rats with congenital diaphragmatic hernias are hypoplastic by not hyperresponsive. J Pediatr Surg 33:1366-1370, 1998.
15. Newell MA, Au-Fliegner M, Coppola CP, Gosche JR. Hypoxic pulmonary vasoconstriction is impaired in rats with nitrofen-induced congenital diaphragmatic hernia. J Pediatr Surg 33:1358-1362, 1998.
16. Coppola CP, Gosche JR, Arrese M, Ancowitz B, Madsen J, Vanderhoof J, Shneider BL. Molecular analysis of the adaptive response of intestinal bile acid transport after ileal resection in the rat. Gastroenterol 115:1172-1178, 1998.
17. Gosche JR, Vukcevic Z, Coppola CP, Reyes-Mugica M. Oxygen induced vasodilation in pulmonary arterioles from fetal rats. J Surg Res 91:95-100, 2000.
18. Coppola CP and Gosche JR. Oxygen induced vasodilation is blunted in pulmonary arterioles from fetal rats with nitrofen induced CDH. J Pediatr Surg 36:593-597, 2001.
19. Gosche JR. Oxygen dilation in fetal pulmonary arterioles: Role of K+ channels. J Surg Res 97:159-163, 2001.
20. Caudill J, Giles H, Megason G, Wyatt-Ashmead J, Gosche J, Nowicki M. Recurrent neuroblastoma with gastric invasion. J Pediatr Hematol Oncol 26: 476-479, 2004.
21. Hua L, Shi D, Bishop PR, Gosche J, May WL, Nowicki MJ. The role of UGT1A1*28 mutation in jaundiced infants with hypertropic pyloric stenosis. Pediatr Res 58(5): 881-884, 2005.
22. Vukcevic Z, Coppola CP, Hults C, Gosche JR. Nitrovasodilator responses in pulmonary arterioles from rats with nitrofen induced CDH. J Pediatr Surg 40:1706-1711, 2005.

Reviews, Chapters, Books:
1. Harbrecht BG, Gosche JR, Larson GM. Sarcomas of the retroperitoneum. KY Med J 85:29-32, 1987.
2. Gosche JR. Evaluation and management of the child with an empty scrotum. Yale Pediatr Update 1(2):1-8, 1994.
3. Gosche JR, Touloukian RJ. Congenital anomalies of the midgut. In Wyllie R. and Hyams J. (eds), Pediatric Gastrointestinal Disease, 2nd edition, W.B. Saunders Co., pp. 505-513, 1999.
4. Gallagher PG, Mahoney MJ, Gosche JR. Cystic hygroma in the fetus and newborn. Semin Perinatol 23:341-456, 1999.
5. Gosche JR. Initial stabilization and transport of the injured child. Mississippi Healthy Baby Update 17(2): 1-8, 2003.
6. Cryer HM, Gosche J, Harbrecht J, Anigian G, Garrison N. The effect of hypertonic saline resuscitation on responses to severe hemorrhagic shock by the skeletal muscle, intestinal, and renal microcirculation systems: seeing is believing. Am J Surg 190(2): 305-13, 2005.
7. Gosche JR, Islam S, Boulanger SC. Congenital diaphragmatic hernia: Searching for answers. Am J Surg 190(2): 324-32, 2005.
8. Gosche JR, Vick L, Boulanger SC, Islam S. Midgut Abnormalities. Surg Clin NA 86(2): 285-99, 2006
9. Gosche JR, Vick L. Acute, subacute and chronic cervical lymphadenitis in children. Semin Pediatr Surg 15(2): 99-106, 2006

Abstracts:
1. Gosche JR, Cryer HM, Garrison RN, Harris PD. Hypertonic saline dextran resuscitation of decompensated hemorrhagic shock attenuates intestinal microvascular reflow. Presented at the 23rd Annual Meeting of the Association for Academic Surgery, Louisville, Kentucky, November 1989.
2. Gosche JR, Garrison RN, Harris PD. Intestinal microvascular responses to hemorrhage in adult and suckling rats. Presented at the Federation of American Societies for Experimental Biology Meeting, Washington, D.C., April 1990. (FASEB J 4(#3): A700)
3. Gosche JR, Garrison RN, Harris PD. Glucose induced absorptive hyperemia reverses decreased intestinal blood flow during E. coli bacteremia in the rat. Presented at the Association of VA Surgeons Annual Meeting, Charleston, South Carolina, May 1990.
4. Gosche JR, Cryer HM, Luebbe AS, Garrison RN. Prostaglandin inhibition does not reverse intestinal arteriolar constriction or improve microvascular blood flow during high cardiac output sepsis. Presented at the 13th Annual Conference on Shock, Durango, Colorado, June 1990. (Circ Shock 31: 49)
5. Gosche JR, Garrison RN. Prostaglandins mediate the compensatory responses to hemorrhage in the small intestine of the rat. Presented at the 24th Annual Meeting of the Association for Academic Surgery, Houston, Texas, November 1990.
6. Gosche JR, Harris PD, Garrison RN, Fallat ME. Comparison of intestinal microvascular responses during low-flow states in adult and suckling rats. Presented at the Eleventh Annual Pediatric Surgical Residents’ Conference, Chicago, Illinois, November 1990.
7. Gosche JR, Harris PD, Garrison RN. Intestinal microvascular responses to hemorrhage are not altered by cyclooxygenase blockade in the suckling rat. Presented at the American Pediatric Surgical Association Annual Meeting, Orlando, Florida, May 1991.
8. Gosche JR, Harris PD, Garrison RN. Comparison of intestinal microvascular responses during low-flow states in adult and suckling rats. Proceedings of the Fifth World Congress for Microcirculation, Louisville, Kentucky. Abstract #190, p. 32, 1991.
9. Besner G, Qualman, Gosche J. Identification of a duplicated undescended testicle- An unexpected benefit of laparoscopic localization. Presented at the IV International Congress for Endosurgery in Children, Orlando, Florida, May 1995.
10. Bensard DD, Gosche JR, Kosloske AM. Bi-directional feeding of an aganglionic myectomized intestinal loop. Presented at the American Pediatric Surgical Association Annual Meeting, Boca Raton, Florida, May 1995.
11. Coppola C, Au-Fliegner M, Newell M, Salami S, Gosche J. Fetal rat isolated pulmonary vessel response to endothelin-1. Presented at Experimental Biology ‘97, New Orleans, Louisiana, April 1997.
12. Newell MA, Coppola CP, Au-Fliegner M, Gosche JR. Hypoxic vasoconstriction is impaired in pulmonary arterioles from rats with nitrofen-induced congenital diaphragmatic hernias. Presented at the 1997 Annual ELSO Meeting, Detroit, Michigan, September 1997.
13. Newell MA, Au-Fliegner M, Coppola C, Gosche JR. Hypoxic pulmonary vasoconstriction is impaired in rats with nitrofen-induced congenital diaphragmatic hernias. Presented at the Annual Meeting of the American Academy of Pediatrics, Section on Surgery, New Orleans, Louisiana, October 1997.
14. Au-Fliegner M, Salami S, Gosche J. Pulmonary arterioles from rats with congenital diaphragmatic hernia (CDH) are hypoplastic but not hyperresponsive. Presented at the Annual Meeting of the American Academy of Pediatrics, Section on Surgery, New Orleans, Louisiana, October 1997.
15. Au-Fliegner M, Coppola C. Gosche J. Pulmonary arteriole from rats with CDH have increased sensitivity to endothelin-1, Presented at the 31st Annual Meeting of The Association for Academic Surgery, Dallas, Texas, November 1997.
16. Coppola CP, Parilla NW, Gosche JR. Oxygen vasodilation is impaired in pulmonary arterioles in rats with nitrofen-induced congenital diaphragmatic hernia. Presented at Biomedicine ‘98, Washington, D.C., May 1998. (J Invest Med 46: 223A)
17. Horwitz JR, Seashore JH, Gosche JR, Touloukian RJ. Pediatric ovarian masses: The unsuspected risk of malignancy. Presented at the 1998 Combined Annual Meeting of the CT Chapter of the ACS and the CT Society of ABS, Cromwell, Connecticut, December 1998.
18. Roros JG, Gosche JR, Seashore J, Dudrick SJ, Touloukian R. Management of blunt pancreatic injuries in children in the 90's: A retrospective analysis. Presented at the 1998 Combined Annual Meeting of the CT Chapter of the ACS and the CT Society of ABS, Cromwell, Connecticut, December 1998.
19. Coppola C, Parilla NW, Gosche JR. Oxygen vasodilation is impaired in pulmonary arterioles from rats with nitrofen-induced congenital diaphragmatic hernia. Presented at the 30th Annual Meeting of the American Pediatric Surgical Association, Rancho Mirage, California, May 1999.
20. Coppola CP, Kitano Y, Jarrett B, Gosche JR, Flake AW. Endothein-induced pulmonary vasoconstriction after tracheal ligation in rats with nitrofen-induced diaphragmatic hernia. Presented at the 1999 Annual Meeting of the Surgical Section of the American Academy of Pediatrics, Washington, D.C., October 1999.
21. Vukcevic Z, Coppola C, Gosche JR. Pulmonary arterioles from rat pups with nitrofen induced CDH do not respond to sodium nitroprusside. Presented at the 1999 Annual Meeting of the Surgical Section of the American Academy of Pediatrics, Washington, D.C., October 1999.
22. Gosche JR. Responses to exogenous arachidonic acid are altered in the pulmonary arterioles of rats with nitrofen induced CDH. Presented at the 31st Annual Meeting of the American Pediatric Surgical Association, Orlando, FL, May 2000.
23. Gosche JR. Voltage Gated Potassium (Kv) Channel Blockade Blunts Oxygen Induced Vasodilation in Pulmonary Arterioles from Term Fetal Rats. Presented at the 34th Annual Meeting of the Association for Academic Surgery (plenary session), Tampa, FL, November 2000.
24. Gosche JR, Hults C. Changing hypoxic vasoconstrictor responses in the immediate perinatal period: Effect of nitric oxide and prostaglandins. Presented at the American Thoracic Society, 97th International Conference, San Francisco, CA, May 2001.
25. Case RC, Islam S, Miller RC, Gosche JR. Age at diagnosis correlates with functional outcome in patients with Hirschsprung’s disease. Presented at the 38th Annual Meeting of the Pacific Association of Pediatric Surgeons, Vancouver, BC, May 2005.
26. Vick LR, Gosche JR, Islam SM, Boulanger SC. Primary laparoscopic repair of high imperforate anus in males. Presented at the American Academy of Pediatrics, Section on Surgery, 2005 National Conference and Exhibition, Washington, DC, October 2005.
27. Rout UK, Clausen P, Vick L, Dhossche DM, Gosche JR. NGF-induced differentiation of PC12 cells in putative pharmacological models of autistic spectrum disorder. 53rd Annual Meeting, Society for Gynecologic Investigation, Toronto, Canada, March 2006. (J Soc Gynecol Invest, 13(2):200A).
28. Rout UK, Dhossche DM, Gosche JR. Drugs and the migration of HTR-8/SVneo cells. 53rd Annual Meeting, Society for Gynecologic Investigation, Toronto, Canada, March 2006. (J Soc Gynecol Invest, 13(2):201A).
29. Boulanger SC, Brisseau GF, Gosche JR. Minimally invasive management of post-traumatic bile leaks. Presented at the 15th Annual Congress for Endosurgery in Children, Dallas, TX, April 2006 (J Laparoendo Adv Surg Tech 16(2): 230)
30. Islam S, Gosche JR, Wyatt-Ashmead J, Vick LR, Abel TR. Gastric electrical stimulation for adolescents with intractable nausea and gastroparesis. Presented at the 37th Annual meeting of the American Pediatric Surgical Association, Hilton Head, SC, May 2006

Other Activities:

Grant Support-
Co-investigator, Medical Research Development Funds, Ohio State University, Department of Surgery, “An Investigation into the Use of Bioelectric Impedance Monitoring to Detect Intestinal ischemia in Animal Models of Necrotizing Enterocolitis”, Ann Kosloske, Principal investigator, 7/1/1993-6/30/1994, $5,000.

Principal investigator, Ohse Research Grant, Department of Surgery, Yale University School of Medicine, “Pulmonary Vascular Reactivity in an Experimental Model of Congenital Diaphragmatic Hernia”, 1/1/1995-12/31/1995, $4,930.

Principal investigator, Ohse Research Grant, Department of Surgery, Yale University School of Medicine, “Endothelium-dependent Vasodilation in Isolated Perfused Pulmonary Arterioles from Fetal Rats with Nitrofen-induced Congenital Diaphragmatic Hernias”, 1/1/1997-12/31/1997, $7,000.

Principal investigator, Ohse Research Grant, Department of Surgery, Yale University School of Medicine, “Mediators of Hypoxic Pulmonary Vasoconstriction in Pulmonary Arterioles of Rats with Nitrofen-Induced Congenital Diaphragmatic Hernias”, 1/1/1998-12/31/1998, $9,975.

Principal investigator, Research Grant (#RG-004-N), American Lung Association of Connecticut, “Pulmonary Vasodilation in Congenital Diaphragmatic Hernia”, 7/1/1998-6/30/2000, $21,000/yr.

Principal investigator, Ohse Research Grant, Department of Surgery, Yale University School of Medicine, “Vasodilator Prostaglandins in an Animal Model of Congenital Diaphragmatic Hernia”, 1/1/2000-12/31/2000, $7,000.

Co-investigator, Center for Psychiatric Neuroscience, “Prenatal Alcohol, Integrins and Neuronal Migration Disorder”, Ujjwal Rout, PhD, principal investigator, 7/1/2005-6/30/2007, $50,000/year.