Wei Zhong Wang, M.D.
Associate Professor

Department of Surgery
University of Nevada School of Medicine, Las Vegas
2040 W. Charleston Blvd., Suite 301
Las Vegas, NV 89102, USA
E-Mail Address: wzwang2000@yahoo.com
Office Phone: 702-895-2893

Certification update

1993: Qualification Certificate Chief Surgeon, Orthopaedic Surgery, Shanghai Second Medical University, Shanghai, China

Education

1988: Shanghai Second Medical University, Shanghai Master of Medicine Degree (Major: Orthopaedic Surgery).

1975: Shanghai Second Medical University, Shanghai (Medicine).

Post-Graduate Training

1994-1997: Postdoctoral Research Associate. Center for Applied Microcirculatory Research, University of Louisville, Louisville

90-93, 94-00: Clinic and Research Associate. Christine M. Kleinert Institute for Hand and Microsurgery, Louisville

1975-1980: Surgical Residency. Ren Ji Hospital, Affiliated with Shanghai Second Medical University, Shanghai

Work History

2000-Present: Associate Professor. Department of Surgery, University of Nevada School of Medicine, Las Vegas

1997-2000: Assistant Professor. Center for Applied Microcirculatory Research, University of Louisville, Louisville

1994-1997: Postdoctoral Research Associate. Center for Applied Microcirculatory Research, University of Louisville, Louisville

1994-2000: Clinic and Research Associate. Christine M. Kleinert Institute for Hand and Microsurgery, Louisville

1993-1994: Chief Surgeon, Orthopaedic Surgery, Shanghai Second Medical University, Shanghai

1990-1993: Clinic and Research Fellow. Christine M. Kleinert Institute for Hand and Microsurgery, Louisville

1985-1990: Attending Surgeon in Orthopaedic Surgery, Shanghai Second Medical University, Shanghai

1980-1985: Surgeon in General Surgery, Shanghai Second Medical University, Shanghai

1975-1980: Resident in General Surgery, Shanghai Second Medical University, Shanghai

Publications (selected in U.S.A. & International Journals only)

1. WZ. Wang, Xin-Hua Fang, Linda L. Stephenson, Richard C. Baynosa, Kayvan T. Khiabani, William A. Zamboni. Microcirculatory Effects of Melatonin in Rat Skeletal Muscle after Prolonged Ischemia. J Pineal Res, In Press.
2. WZ. Wang, XH Fang, LL. Stepheson, KT. Khiabani and WA. Zamboni. Acute Microvascular Action of Vascular Endothelial Growth Factor in Skeletal Muscle Ischemia/Reperfusion Injury. Plast Reconstruc Surg. In Press.
3. KT. Khiabani, LL. Stepheson, A. Gabriel, C Nataraj, WZ. Wang and WA. Zamboni. “A Quantitative Method for Determining Polarization of Neutrophil Adhesion Molecules Associated with Ischemia Reperfusion” Plast Reconstruc Surg, 114(7): 1846-1850, 2004.
4. WZ. Wang, XH Fang, LL. Stepheson, KT. Khiabani and WA. Zamboni. “Ischemic Preconditioning-Induced Microvascular Protection at a Distance” J Reconstruc Microsurg, 20(2): 61-67, 2004.
5. WZ. Wang, XH Fang, LL. Stepheson, KT. Khiabani and WA. Zamboni. “NOSs Upregulation attenuates vascular endothelial dysfunction in the late phase of ischemic preconditioning in skeletal muscle” J Orthop Res, 22(3): 578-585, 2004.
6. WZ. Wang, Seth Jones, LL. Stepheson, KT. Khiabani and WA. Zamboni “Microvascular Protection Induced by Late Preconditioning Abloshed in STZ-Induced Diabetic Rats” J Reconstruc Microsurg, 18(8):389-396, 2002
7. WZ. Wang, LL. Stepheson, GL. Anderson, FN. Miller, KT. Khiabani and WA. Zamboni “Role of PKC in Microvascular Protection Induced by Late Preconditioning” J Surg Res. 106(1): 166-172, 2002
8. WZ. Wang: (Invited Chapter) “Intervention Approaches against I/R-induced Arterial Insufficiency in Reconstructive Microsurgery. Hand Clinics 17(3): 357-369, 2001
9. WZ. Wang, SZ. Guo, TM, Tsai, G. Anderson, and FN. Miller “The initiating factors of late preconditioning in the microcirculation of skeletal muscle” J Surg Res. 99, 92-99, 2001
10. WZ. Wang, SZ. Guo, TM, Tsai, G. Anderson, and FN. Miller “The initiation of microvascular protection by nitric oxide in the late preconditioning” J Reconstruc Microsurg 16(8): 621-628, 2000
11. WZ. Wang, SZ. Guo, TM, Tsai, G. Anderson, and FN. Miller “Platelet-activating factor contributes to postischemic vasospasm” J Surg Res, 89, 139-146, 2000
12. WZ. Wang, TM, Tsai, G. Anderson. “Late preconditioning protection is evident in the microcirculation of skeletal muscle” J Orthop Res, 17(4):571-577, 1999
13. R.J.P.M. Franken, P.M.N. Werker, FW. Peter, M.L.E. Overgoor, WZ. Wang, GL.Anderson, DA, Schuschke, JC. Banis, M. Kon, and JH. Barker. “Microcirculatory changes following different temperature washouts in a free flap model” Microsurgery 19: 214-222, 1999
14. WZ. Wang, G. Anderson, J Firrell, TM. Tsai. “Ischemic preconditioning vs. Intermittent reperfusion to improve blood flow to a vascular isolated skeletal muscle flap of rats” J Trauma. 45 (5): 953-959, 1998
15. FW. Peter, DA. Schuschke, WZ. Wang, et al. " Do leukocytes contribute to impaired microcircular tissue perfusion after arterial repair ? ". Microsurgery. 18:23-28, 1998
16. WZ. Wang, G. Anderson, JT. Fleming, et al. “Lack of nitric oxide contributes to vasospasm during ischemia/reperfusion injury”. Plast Reconstruc Surg, Vol. 99, No. 4, 1099-1108, 1997
17. WZ. Wang, G. Anderson, RD. Acland et al. “Endothelin-1 does not contricbute to ischemia/reperfusion-induced vasoconstriction in skeletal muscle”. J Reconstruc Microsurg, Vol. 13, No. 6, 439-447, 1997
18. FW. Peter, RJRM Franken, WZ. Wang, et al. “ The effect of low dose aspirin on thrombus formation at arterial and venous microanastomoses ans on the tissue micrcirculation”. Plast Reconstruc Surg, Vol. 99, No. 4, 1112-1121, 1997
19. WZ. Wang, G. Anderson, C. Maldonado, et al. “ Attenuation of vasospasm and capillary no-reflow by ischemic preconditioning in skeletal muscle”. Microcirculation. Vol. 4, No. 1, 174, 1997
20. RJRM. Franken, FW. Peter, WZ. Wang, et al. “The anatomy of the feeding blood vessels of the cremaster muscle in the rat” Microsurgery. Vol. 17, No. 7, 402-408, 1996
21. WZ. Wang and TM Tsai. “ Outcome of digital nerve injuries in adults” J Hand Surg 21A, 138-143, 1996
22. FW. Peter, RJRM Franken, WZ. Wang, et al. “ Tissue and anastomotic protection in microvascular surgery: the effect of low dose aspirin” Surg. Forum 47: 744-746, 1996
23. WZ. Wang, G. Anderson, C. Maldonado, et al. “ Attenuation of vasospasm and capillary no-reflow by ischemic preconditioning in skeletal muscle”. Microsurgery. Vol. 17, No. 6, 324-329, 1996
24. WZ. Wang, G. Anderson, J Firrell. “Arteriole constriction following ischemia in denervated skeletal muscle” J Reconstruc Microsurg Vol. 11 (2): 99-106, 1995
25. WZ. Wang, G. Anderson, JT. Fleming, et al. “Lack of Nitric Oxide contributes to vasospasm during ischemia/reperfusion injury”. Microcirculation. Vol. 2(1): 66, 1995
26. RJRM. Franken, FW. Peter, WZ. Wang, et al. “Microcirculatory changes following different temperature washouts in free flap muscle” Eur. Surg. Res. 27(suppl 1): 100-102, 1995
27. TM. Tsai, WZ. Wang. “Vascularized joint transfers: Indications and results” Hand Clinics Vol. 8 (3): 525-536, 1992
28. M. Siemionow, WZ. Wang, G. Anderson and JC. Firrell. “Leukocyte-endothelial interaction capillary perfusion in ischemia/reperfusion of the rat cremaster muscle” Microcirc. Endoth. Lymphatics, Vol. 7:187-197, 1991

Presentations (selected in U.S.A. & International Conferences only)

1. “Microvascular Effects of Melatonin in Skeletal Muscel”. Annual Meeting of American Society of Reconstrictive Microsurgery, Jan 15-18, 2005, Purto Rico.
2. “Acute Microvascular Action of Vascular Endothelial Growth Factor in Skeletal Muscle Ischemia/Reperfusion Injury”. 49th Annual Meeting of the Plastic Surgery Research Council, to be held June 9-12, 2004 in Ann Arbor, Michigan.
3. “The effect of hyperbaric oxygen on nitric oxide synthase and vascular endothelial growth factor expression in ischemia reperfusion injury”. 49th Annual Meeting of the Plastic Surgery Research Council, to be held June 9-12, 2004 in Ann Arbor, Michigan.
4. “Ischemia reperfusion: NOS inhibition reverses the effect of HBO on neutrophil adhesion in vivo “. 49th Annual Meeting of the Plastic Surgery Research Council, to be held June 9-12, 2004 in Ann Arbor, Michigan.
5. “The effect of isoform-selective nitric oxide synthase inhibitors on PMN CD18/11b polarization in ischemia-reperfusion injury”. 49th Annual Meeting of the Plastic Surgery Research Council, to be held June 9-12, 2004 in Ann Arbor, Michigan.
6. “Ischemia reperfusion injury”. Distinguish Lecture for 9th Congress of Chinese Medical Association for Surgery of the Hand. May 22-27, 2004, Shanghai
7. “Ischemia reperfusion injury in Reconstrictive Microsurgery”. Invited Lecture for 7th Hand Forum, Apr 9-11, 2004, Las Vegas.
8. “Adenosine is not the initiating factor for remote ischemic preconditioning”. Annual Meeting of American Society of Reconstrictive Microsurgery, Jan 17-20, 2004, Palms Springs, CA.
9. “Nitric Oxide Synthases upregulation in the Late Phase of Ischemic Preconditioning in the Skeletal Muscle", for presentation at the 48th Annual Meeting of the Plastic Surgery Research Council, to be held April 23-26, 2003, Las Vegas.
10. “Microcirculatory Protection of Skeletal Muscle in Remote Preconditioning", for presentation at the 48th Annual Meeting of the Plastic Surgery Research Council, to be held April 23-26, 2003, Las Vegas.
11. “Nitric Oxide Sythases Expression in the Late Phase of Ischemic or Adenosine Preconditioning in the Skeletal Muscle” American Society of Reconstrictive Microsurgery, Hawaii, Jan 12-15, 2003.
12. “HBO Inhibits IR Induced Neutrophil CD 18 Polarization by a Nitric Oxide Mechanism” the 47th Annual Meeting of the Plastic Surgery Research Council, Boston, Massachusetts, April, 2002
13. “Late preconditioning in the microcirculation of skeletal muscle of STZ-induced diabetic rats” the 47th Annual Meeting of the Plastic Surgery Research Council, Boston, Massachusetts, April, 2002
14. “Role of PKC in Microvascular Protection in the Late Phase of Ischemic- or Adenosine Preconditioning in Skeletal Muscle” the 47th Annual Meeting of the Plastic Surgery Research Council, Boston, Massachusetts, April, 2002
15. “PKC Contributes to Microvascular Protection Induced by Delayed Ischemic Preconditioning in Skeletal Muscle” American Society of Reconstrictive Microsurgery, Jan 12-15, 2002, Cancun, Mexico, Jan. 2002.
16. “Late Preconditioning Attenuates Vascular Endothelium Dysfunction after Prolonged Ischemia/Reperfusion in Skeletal Muscle” Inaugural Congress of the World Society for Reconstructive Microsurgery. Taipei, Taiwan, Oct. 2001
17. “The Initiating Factors of Late Preconditioning in Skeletal Muscle” 46th Annual Meeting of The Plastic Surgery Research Council, Milwaukee, Wisconsin, April, 2001
18. “The Initiating Factor of Late Preconditioning” Nevada Biomedical Research and Education Conference. Las Vegas, March, 2001
19. “The Role of PAF on Reperfusion-Induced Endothelium Dysfunction” Nevada Biomedical Research and Education Conference. Las Vegas, March, 2001
20. “The initiation of microvascular protection by nitric oxide in the late preconditioning” 47th Annual Conference of the Microcirculatory Society, inc. San Diego. 2000
21. “Platelet-activating factor contributes to postischemic vasospasm” 47th Annual Conference of the Microcirculatory Society, inc. San Diego. 2000
22. “Late preconditioning protection is evident in the microcirculation of skeletal muscle” 46th Annual Conference of the Microcirculatory Society, inc. Washington, DC. 1999
23. “ischemic preconditioning vs. intermittent reperfusion to improve flow to a vascular isolated skeletal muscle flap of rats”. 13th annual meeting, American Society of Reconstructive Microsurgery, Scottsdale, Arizona, Jan 3-7, 1998
24. “ischemic preconditioning vs. intermittent reperfusion to improve flow to a vascular isolated skeletal muscle flap of rats”. Vascular Biology’98, San Francisco, CA. 1998
25. “Attenuation of vasospasm and capillary no-reflow by ischemic preconditioning in skeletal muscle”. Vascular Biology’97, New Orleans, Louisiana, April 3-6, 1997
26. “Role of nitric oxide in mediating the delay phenomenon” 42th annual meeting, Plastic Surgery Research Council. Galveston, Texas. Feb. 26-March 1, 1997
27. “Endothelin-1 does not contricbute to ischemia/reperfusion-induced vasoconstriction in skeletal muscle”. 12 th annual meeting, American Society of Reconstructive Microsurgery. Boca Raton, FL. Jan. 1-15, 1997
28. “The effect of low dose aspirin on thrombus formation at arterial and venous microanastomoses ans on the tissue micrcirculation”. 41th annual meeting of Plastic Surgery Research Council. St. Louis, MO, June 1-4, 1996
29. “The effect of low dose aspirin on thrombus formation at arterial and venous microanastomoses ans on the tissue micrcirculation”. 6th World Congress for Microcirculation. Munich, Germany. August 25-30, 1996
30. “Local infusion of nitricprusside but not acetylcholine attenuates vasospasm and no-reflow associated with prolonged warm ischemia-reperfusion in the vascular isolated cremaster muscle”. 41th Annual Meeting of the Plastic Surgery Research Council. New York, New York. 1995
31. “Microcirculatory changes following different temperature washouts in free flap muscle” 15th Congress of European Society for Surgical Research, Amsterdam, 1995
32. “Local infusion of nitricprusside but not acetylcholine attenuates vasospasm and no-reflow associated with prolonged warm ischemia-reperfusion in the vascular isolated cremaster muscle”. 42th Annual Meeting of the Microcirculatory Society, inc. Atlanta, GA. 1995
33. “Outcome of digital nerve injuries in adults” Annual Meeting. American Society for Hand Surgery. St Louis, 1993
34. “Denervation enhances vessel reactivity following ischemia in skeletal muscle” 8th Annual Meeting, American Society for Reconstructive Microsurgery. Scottsdale, Arizona, 1992
35. “Neutrophil number does not influence capillary perfusion in ischemia reperfusion” 8th Annual Meeting. American Society for Reconstructive Microsurgery. Scottsdale, Arizona, 1992

Teaching:

Microsurgery Skill Training Course: for residences in Department Surgery.

Research Grants (selected in U.S.A. only):

Agency: Plastic Surgery Education Foundation (PSEF)
Grant Title: “I/R injury in the microcirculation of skeletal muscle”
Position: Principal Investigator
Status: Funded: $4,000 for 1 year (7/04 -6/05)

Agency: National Institutes of Health
Grant Title: “Microcirculatory protection in late preconditioning”
Position: Principal Investigator
Status: Funded: $200,000 per year, inclusive dates (10/00 - 1/03)

Agency: American Heart Association
Grant Title: “Late Preconditioning in Microcirculation”
Position: Principal Investigator
Status: Funded: $70,000 for two years.

Agency: Orthopaedic Research and Education Foundation
Grant Title: “The role of platelet-activating factor in ischemia/reperfusion injury of skeletal muscle”
Position: Principal Investigator
Status: Funded: $64,059 for two years, inclusive dates (7/98 - 12/00)

Agency: Christine M, Kleinert Institute for Hand and Micro Surgery
Project: “Late Preconditioning Protection is Evident in the Microcirculation of Skeletal Muscle”
Position: Principal Investigator
Status: Funded: $40,000 for the project (1/00-1/01)

Agency: Jewish Hospital Foundation
Grant Title: “The role of NO in replantation and free flap failure”
Position: Co-Investigator to Robert D. Acland, M.D.
Status: Funded: Total of $ 40,595 for 2 year grant, inclusive dates (3/95 - 2/97)